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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF4E
All Species:
34.55
Human Site:
Y183
Identified Species:
47.5
UniProt:
P06730
Number Species:
16
Phosphosite Substitution
Charge Score:
-0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P06730
NP_001959.1
217
25097
Y183
V
T
H
I
G
R
V
Y
K
E
R
L
G
L
P
Chimpanzee
Pan troglodytes
XP_523824
217
24938
Y183
V
T
H
I
G
R
V
Y
K
E
R
L
G
L
P
Rhesus Macaque
Macaca mulatta
XP_001092045
253
28850
Y219
V
L
H
I
G
R
V
Y
K
E
R
L
G
L
S
Dog
Lupus familis
XP_544992
217
25075
Y183
V
T
H
I
G
R
V
Y
K
E
R
L
G
L
P
Cat
Felis silvestris
Mouse
Mus musculus
Q3UTA9
244
27967
Y211
V
M
Q
I
G
Q
I
Y
K
E
R
L
G
I
S
Rat
Rattus norvegicus
P63074
217
25035
Y183
V
T
H
I
G
R
V
Y
K
E
R
L
G
L
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514651
236
27161
F198
L
C
L
I
G
E
S
F
D
D
Y
S
D
D
V
Chicken
Gallus gallus
XP_420655
217
25026
Y183
V
T
H
I
G
R
V
Y
K
E
R
L
G
L
P
Frog
Xenopus laevis
P48597
213
24616
Y179
V
T
H
I
G
R
V
Y
K
E
R
L
G
L
P
Zebra Danio
Brachydanio rerio
Q9DFS6
215
24831
Y181
I
V
H
I
G
R
V
Y
K
E
R
L
G
V
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P48598
259
29205
L225
A
L
E
I
G
H
K
L
R
D
A
L
R
L
G
Honey Bee
Apis mellifera
XP_624290
213
24784
L179
V
M
E
I
G
R
K
L
R
E
R
L
K
I
A
Nematode Worm
Caenorhab. elegans
O61955
248
27791
L178
N
L
R
I
G
Q
V
L
K
Q
K
L
S
I
P
Sea Urchin
Strong. purpuratus
NP_001091928
225
25645
F191
I
T
N
I
G
R
K
F
K
E
R
L
G
L
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
O81481
218
24452
K185
A
A
Q
V
S
I
G
K
Q
W
K
E
L
L
D
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O23252
235
26501
K202
A
A
Q
V
S
I
G
K
Q
W
K
E
F
L
D
Baker's Yeast
Sacchar. cerevisiae
P07260
213
24236
G179
K
E
P
L
L
R
I
G
G
K
F
K
Q
V
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.6
59.2
99.5
N.A.
53.2
98.1
N.A.
71.6
92.1
88.4
82.9
N.A.
43.6
54.8
41.1
53.7
Protein Similarity:
100
98.6
69.1
99.5
N.A.
69.2
98.6
N.A.
74.1
94
94
92.6
N.A.
56.3
68.6
58.8
73.7
P-Site Identity:
100
100
86.6
100
N.A.
60
100
N.A.
13.3
100
100
80
N.A.
26.6
46.6
40
73.3
P-Site Similarity:
100
100
86.6
100
N.A.
80
100
N.A.
33.3
100
100
93.3
N.A.
40
60
66.6
93.3
Percent
Protein Identity:
N.A.
42.2
N.A.
39.5
31.8
N.A.
Protein Similarity:
N.A.
56.8
N.A.
54
55.3
N.A.
P-Site Identity:
N.A.
6.6
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
26.6
N.A.
26.6
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
18
12
0
0
0
0
0
0
0
0
6
0
0
0
6
% A
% Cys:
0
6
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
6
12
0
0
6
6
12
% D
% Glu:
0
6
12
0
0
6
0
0
0
65
0
12
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
12
0
0
6
0
6
0
0
% F
% Gly:
0
0
0
0
83
0
12
6
6
0
0
0
59
0
6
% G
% His:
0
0
48
0
0
6
0
0
0
0
0
0
0
0
0
% H
% Ile:
12
0
0
83
0
12
12
0
0
0
0
0
0
18
0
% I
% Lys:
6
0
0
0
0
0
18
12
65
6
18
6
6
0
0
% K
% Leu:
6
18
6
6
6
0
0
18
0
0
0
77
6
65
6
% L
% Met:
0
12
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
6
0
6
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
6
0
0
0
0
0
0
0
0
0
0
0
53
% P
% Gln:
0
0
18
0
0
12
0
0
12
6
0
0
6
0
0
% Q
% Arg:
0
0
6
0
0
65
0
0
12
0
65
0
6
0
0
% R
% Ser:
0
0
0
0
12
0
6
0
0
0
0
6
6
0
12
% S
% Thr:
0
42
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
53
6
0
12
0
0
53
0
0
0
0
0
0
12
6
% V
% Trp:
0
0
0
0
0
0
0
0
0
12
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
53
0
0
6
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _